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This volume involves the papers ready by the invited speakers as properly as numerous of the cost-free communications. The contributions are grouped in accordance to their standard subject subject, primarily based on the classification made by the authors, e.g., Extracellular Metabolism: Calcium Homeostasis Reduced-Affinity Calcium- Binding Proteins. The highlights of the symposium are many. Amongst the objects of note are the extraordinary strides accomplished by X-ray crystallography in unravelingMCE Company XL335 the 3-dimensional composition of the calcium-binding proteins, like calmodulin, calbindin-D9K (the vitamin D-induced calcium-binding protein), parvalbumin, and troponin C. In addition, new structural info has emerged as a consequence of the application of nuclear magnetic resonance (NMR) to the study of these calcium-binding proteins. Another location of target is the molecular biology of the calcium-binding proteins. Comprehensive information is introduced both on the cDNA and on the genomic DNA of calmodulin, calbindin-D9K and κ>2 8parvalbumin, and the spec gene household in sea urchins and aequorin. Finally, internet site-directed mutagenesis, which is currently being used successfully to take a look at composition-function interactions of the calcium-binding protein family, is pressured. There can be small question that calcium-binding proteins is a discipline of scientific endeavor which will carry on to produce benefits of fantastic interest to present day biology. The Organizing Committee would like to accept the financial support of Bayer AG Miles Laboratories Beckman Devices, Inc. Chugai Pharmaceutical Firm Ltd. Glaxo, Inc. Hoechst AG (Frankfurt/Primary, West Germany) Hoffmann-La Roche, Inc. (Nutley, New Jersey) Marion Laboratories Merck Sharp & Dohme Analysis Laboratories Countrywide Dairy Council Norwich Eaton Pharmaceuticals, Inc./Procter & Gamble Organization Teijin Institute for Bio-Healthcare Analysis and the University of California- Riverside, Division of Biomedical Sciences. With out this generous multicorporate financial support, this symposium would never ever have taken location. A special tribute is owing to the tireless attempts of the convention secretary, Mrs. Sharon Herbert, and her colleague in Riverside Ms. June E. Bishop. They have been dependable for the bulk of the secretarial pursuits related to the production of the abstracts and the progress registration method.